While the key ingredient in VG750 expedites the rate of bone healing and dramatically increases tensile strength a fact which is scientifically amazing and is of great significance for K-9’s suffering from broken bones and fractures it is the anti-glucocorticoid properties of Cissus Quadrangularis the key ingredient found in VG750 which is vital in maintaining strong joint conformation for the life of a K-9. Since endogenous glucocorticoids, particularly cortisol, are not only catabolic (deteriorate) to bone, which also catabolize (break down) muscle tissue as well. Numerous studies over the years have suggested that glucocorticoids, including the body’s endogenous hormone cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. A recently published report documented exactly how glucocorticoids (including cortisol) induce muscle breakdown: They activate the so-called ubiquitin-proteasome pathway of proteolysis. This pathway of tissue breakdown is important for removing damaged and non-functional proteins. However, when it is overactive during periods of elevated cortisol release (e.g. disease states, stress from injury, and excessive exercise) excess amounts of normal tissue are broken down as well. By exerting an anabolic, anti-glucocorticoid effect, VG750 helps preserve muscle tissue during times of physical and mental stress acting as a glucocorticoid antagonist (inhibits the release of cortisol) in addition to the natural anti-inflammatory and analgesic properties. VG750 promotes the ability for tendons, ligaments and connective tissue to heal faster. The fact is maintaining stronger muscle surrounding joint conformation minimizes the structural damage to the joints which inevitably leads to severe mobility issues as the age of the K-9 increases.